Association of kidney function with dementia and brain pathologies: A community‐based cohort study

Background Kidney function has been linked to cognitive function, but its relation dementia and mechanisms underlying this remains unclear. We aimed examine the association of impaired kidney with brain pathologies. Method Within Rush Memory Aging Project, 1380 dementia-free subjects (75.22% female; mean age: 79.42±7.61 years) at baseline were followed for up 22 years. Blood samples taken serum creatinine was measured calculate estimated glomerular filtration rate (eGFR) using Modification Diet in Renal Disease formula. dichotomized as normal (eGFR ≥ 60 mL/min/1.73 m2) or <60 m2). Dementia, including Alzheimer’s dementia, diagnosed following international criteria. During follow-up, 469 participants died underwent autopsies neuropathological assessment (including disease [AD], vascular, other pathologies). Data analyzed Cox regression, Laplace logistic regression. Result At baseline, 895 (64.86%) 485 (35.14%) impaired. Over follow-up (median [interquartile range]: 5 [2–9] years), 300 (21.74%) developed 273 (19.78%) dementia. In multi-adjusted lower eGFR does-dependently associated higher risk (hazard ratio [HR] = 1.01, 95% confidence interval [CI]: 1.01–1.02, P 0.003) (HR CI: 1.00-1.02, 0.002). Compared a greater 1.49, 1.16–1.91) 1.45, 1.12–1.89). The median time development 2.48 (95% 0.36–3.03) 2.56 0.37–2.79) years shorter people vs. respectively. pathology analysis, significantly related burdens cerebral amyloid angiopathy (odds 2.03, 1.23–3.35). Conclusion Impaired is an increased Vascular may underlie association.